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doi:10.1534/genetics.106.062976
A more recent version of this article appeared on January 1, 2007.
REGULAR RESEARCH PAPERS |
Disruption of genetic interaction between two autosomal regions and the X chromosome causes reproductive isolation between mouse strains derived from different subspecies
Ayako Oka 1, Toshihiro Aoto 2, Yoshikazu Totsuka 2, Riichi Takahashi 2, Masatsugu Ueda 2, Akihiko Mita 1, Noriko Sakurai-Yamatani 1, Hiromi Yamamoto 1, Satoshi Kuriki 3, Nobuo Takagi 4, Kazuo Moriwaki 5 and Toshihiko Shiroishi 1*
1 National Institute of Genetics
2 The YS Institute, Inc
3 The Institute of Statistical Mathematics
4 Hokusei Gakuen University
5 RIKEN BioResource Center
* To whom correspondence should be addressed. E-mail: tshirois{at}lab.nig.ac.jp.
Submitted on July 5, 2006
Revised on September 13, 2006
Accepted on 11 October 2006
Reproductive isolation that initiates speciation is likely caused by incompatibility between multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossinus, genetically close to M. m. musculus) are reproductively isolated. Their F1 hybrids are fertile, but successive intercrosses result in sterility. A consomic strain, C57BL/6J-ChrXMSM, which carries the X chromosome of MSM/Ms in the C57BL/6J background, shows male sterility, suggesting a genetic incompatibility of the MSM/Ms X chromosome and other C57BL/6J chromosome(s). In this study, we conducted genome-wide linkage analysis and subsequent QTL analysis using the sperm shape anomaly that is the major cause of the sterility of the C57BL/6J-ChrXMSM males. These analyses successfully detected significant QTLs on chromosomes 1 and 11 that interact with the X chromosome. The introduction of MSM/Ms chromosomes 1 and 11 into the C57BL/6J-ChrXMSM background failed to restore the sperm head shape, but did partially restore fertility. These suggest that this genetic interaction may play a crucial role in the reproductive isolation between the two strains. A detailed analysis of the male sterility by intracytoplasmic sperm injection and zona-free in vitro fertilization demonstrated that the C57BL/6J-ChrXMSM spermatozoa have a defect in penetration through the zona pellucida of eggs.
Key Words: consomic strain, hybrid breakdown, male sterility, mouse, reproductive isolation
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