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doi:10.1534/genetics.106.062885
A more recent version of this article appeared on November 1, 2006.
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Site-Specific Amino Acid Frequency, Fitness, and the Mutational Landscape Model of Adaptation in HIV-1
Jack da Silva 1*
1 The University of Adelaide
* To whom correspondence should be addressed. E-mail: jack.dasilva{at}adelaide.edu.au.
Submitted on July 6, 2006
Revised on July 17, 2006
Accepted on 17 July 2006
Analysis of the intensely studied HIV-1 gp120 V3 protein region reveals that the among-population mean site-specific frequency of an amino acid is a measure of its relative marginal fitness. This surprising result may arise if populations are displaced from mutation-selection equilibrium by fluctuating selection and if the probability of fixation of a beneficial amino acid is proportional to its selection coefficient.
Key Words: adaptation, human immunodeficiency virus, marginal fitness, selection coefficient, site-specific amino acid frequency
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