- THIS ARTICLE
- Full Text (Rapid PDF)
- Data Supplement
-
All Versions of this Article:
genetics.106.061796v1
175/2/917 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Li, D.
- Articles by He, L.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Li, D.
- Articles by He, L.
doi:10.1534/genetics.106.061796
A more recent version of this article appeared on February 1, 2007.
REGULAR RESEARCH PAPERS |
G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies
Dawei Li 1* and Lin He 1
1 Shanghai Jiao Tong University
* To whom correspondence should be addressed. E-mail: dwlidwli{at}gmail.com.
Submitted on June 10, 2006
Revised on September 25, 2006
Accepted on 4 December 2006
ABSTRACT Schizophrenia may result from a neurotransmission hypofunction of glutamatergic and N-methyl-D-aspartate (NMDA) receptors. Linkage disequilibrium mapping has identified several promising and novel positional candidates, including the G72/G30 and D-amino-acid oxidase (DAAO) genes. Since the first positive association report, many subsequent studies have attempted to replicate the association but the results have been mixed. To try to resolve this inconsistency and to elucidate the relationship between the important glutamate-related genes and schizophrenia, the current meta-analysis has combined samples involving 16 polymorphisms covering all published case-control and family-based association studies up to October 2005. The results suggest that there is weak evidence of association between the G72/G30 genes and schizophrenia.
Key Words: Association, Case Control, Chromosome 13q, Single nucleotide polymorphism (SNP), TDT
This article has been cited by other articles:
 |
|
 |
|
  M. Rietschel, L. Beckmann, J. Strohmaier, A. Georgi, A. Karpushova, F. Schirmbeck, K. V. Boesshenz, C. Schmal, C. Burger, R. A. Jamra, et al. G72 and Its Association With Major Depression and Neuroticism in Large Population-Based Groups From Germany Am J Psychiatry, June 1, 2008; 165(6): 753 - 762. [Abstract] [Full Text] [PDF]
|
|