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doi:10.1534/genetics.106.061796
A more recent version of this article appeared on February 1, 2007.
REGULAR RESEARCH PAPERS |
G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies
Dawei Li 1* and Lin He 1
1 Shanghai Jiao Tong University
* To whom correspondence should be addressed. E-mail: dwlidwli{at}gmail.com.
Submitted on June 10, 2006
Revised on September 25, 2006
Accepted on 4 December 2006
ABSTRACT Schizophrenia may result from a neurotransmission hypofunction of glutamatergic and N-methyl-D-aspartate (NMDA) receptors. Linkage disequilibrium mapping has identified several promising and novel positional candidates, including the G72/G30 and D-amino-acid oxidase (DAAO) genes. Since the first positive association report, many subsequent studies have attempted to replicate the association but the results have been mixed. To try to resolve this inconsistency and to elucidate the relationship between the important glutamate-related genes and schizophrenia, the current meta-analysis has combined samples involving 16 polymorphisms covering all published case-control and family-based association studies up to October 2005. The results suggest that there is weak evidence of association between the G72/G30 genes and schizophrenia.
Key Words: Association, Case Control, Chromosome 13q, Single nucleotide polymorphism (SNP), TDT
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