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doi:10.1534/genetics.106.061705
A more recent version of this article appeared on September 1, 2006.
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An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function
T.S. Vivian Liao 1, Gerald B. Call 1, Preeta Guptan 1, Albert Cespedes 1, Jamie Marshall 1, Kevin Yackle 1, Edward Owusu-Ansah 1, Sudip Mandal 1, Q. Angela Fang 1, Gelsey L. Goldstein 1, William Kim 1 and Utpal Banerjee 1*
1 UCLA
* To whom correspondence should be addressed. E-mail: banerjee{at}mbi.ucla.edu.
Submitted on June 8, 2006
Revised on July 6, 2006
Accepted on 6 July 2006
We conducted a screen for glossy-eyed flies which fail to incorporate BrdU in the third larval instar eye disc but exhibit normal neuronal differentiation and isolated 23 complementation groups of mutants. These same phenotypes were previously seen in mutants for cytochrome c oxidase subunit Va. We have molecularly characterized six complementation groups and, surprisingly, each encodes a mitochondrial protein. Therefore, we believe our screen to be an efficient method for identifying genes with mitochondrial function.
Key Words: BrdU, Drosophila, cell cycle, clonal analysis, mitochondria
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