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Genetics. Published Articles Ahead of Print: June 4, 2006, Copyright © 2006
doi:10.1534/genetics.106.060749
doi:10.1534/genetics.106.060749
A more recent version of this article appeared on August 1, 2006.
NOTE |
Deletion Polymorphism of Disc1 is Common to All 129 Mouse Substrains: Implications for Gene Targeting Studies of Brain Function
Steven J Clapcote 1* and John C Roder 1
1 Mount Sinai Hospital
* To whom correspondence should be addressed. E-mail: clapcote{at}mshri.on.ca.
Submitted on May 17, 2006
Revised on May 25, 2006
Accepted on 29 May 2006
Abstract
We report that the Disc1 gene in all extant 129 mouse inbred subtrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.
Key Words: Brain, Deletion, Disc1, Gene targeting, Mouse
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