- THIS ARTICLE
- Full Text (Rapid PDF)
-
All Versions of this Article:
genetics.106.060541v1
174/3/1151 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Pal Bhadra, M.
- Articles by Birchler, J. A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Pal Bhadra, M.
- Articles by Birchler, J. A.
doi:10.1534/genetics.106.060541
A more recent version of this article appeared on November 1, 2006.
REGULAR RESEARCH PAPERS |
Misregulation of Sex-lethal and disruption of MSL complex localization in Drosophila species hybrids
Manika Pal Bhadra 1, Utpal Bhadra 2 and James A. Birchler 3*
1 Indian Institute of Chemical Technology
2 Centre for Cellular and Molecular Biology
3 University of Missouri
* To whom correspondence should be addressed. E-mail: birchlerj{at}missouri.edu.
Submitted on May 9, 2006
Revised on June 15, 2006
Accepted on 7 August 2006
A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans. Sex-lethal (Sxl), a critical gene for sex determination, is misregulated in these hybrids. In hybrid males from D. melanogaster mothers, there is an abnormal expression of Sxl and a failure of localization of the Male Specific Lethal (MSL) complex to the X chromosome, which causes changes in gene expression. Introduction of a Sxl mutation into this hybrid genotype will allow expression of the MSL complex but there is no sequestration to the X chromosome. Lethal hybrid rescue (Lhr), which allows hybrid males from this cross to survive, corrects the SXL and MSL defects. The reciprocal cross of D. simulans mothers by D. melanogaster males exhibits under-expression of Sxl in embryos.
Key Words: Drosophila simulans, MSL complex, Sex-lethal, hybrid incompatibility
This article has been cited by other articles:
 |
|
 |
|
  D. Bachtrog Positive Selection at the Binding Sites of the Male-Specific Lethal Complex Involved in Dosage Compensation in Drosophila Genetics, October 1, 2008; 180(2): 1123 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Bolkan, R. Booker, M. L. Goldberg, and D. A. Barbash Developmental and Cell Cycle Progression Defects in Drosophila Hybrid Males Genetics, December 1, 2007; 177(4): 2233 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Rodriguez, D. Vermaak, J. J. Bayes, and H. S. Malik Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila PNAS, September 25, 2007; 104(39): 15412 - 15417. [Abstract] [Full Text] [PDF]
|
|