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doi:10.1534/genetics.106.060251
A more recent version of this article appeared on October 1, 2006.
REGULAR RESEARCH PAPERS |
Inheritance Patterns of Transcript Levels in F1 Hybrid Mice
Xiangqin Cui 1*, Jason P Affourtit 2, Keith R. Shockley 2, Yong Woo 2 and Gary A Churchill 2
1 University of Alabama at Birmingham
2 The Jackson Laboratory
* To whom correspondence should be addressed. E-mail: xcui{at}uab.edu.
Submitted on May 2, 2006
Revised on May 28, 2006
Accepted on 31 July 2006
Genetic analysis of transcriptional regulation is a rapidly emerging field of investigation that promises to shed light on the regulatory networks that control gene expression. Although a number of such studies have been carried out, the nature and extent of the heritability of gene expression traits has not been well established. We describe the inheritance of transcript levels in liver tissue in the first filial (F1) generation of mice obtained from reciprocal crosses between the common inbred strains A/J and C57BL/6J. We obtained estimates of genetic and technical variance components from these data and demonstrated that shrinkage estimators can increase detectable heritability. Estimates of heritability vary widely from transcript to transcript, with 1/3 of transcripts showing essentially no heritability (<0.01) and 1/4 showing very high heritability (>0.50). Roughly half of all transcripts are differentially expressed between the two parental strains. Most transcripts show an additive pattern of inheritance. Significant dominance effects were observed for 20% of transcripts and a small number of transcripts were identified as showing an overdominance mode of inheritance. In addition, we identified 314 transcripts with expression levels that differ between the reciprocal F1 animals. These genes may be related to maternal effect.
Key Words: Inheritance, Microarray, additive, dominance, heritability
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