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doi:10.1534/genetics.106.056465
A more recent version of this article appeared on June 1, 2006.
REGULAR RESEARCH PAPERS |
Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development
Craig J Ceol 1, Frank Stegmeier 2, Melissa M Harrison 3 and H R Horvitz 3*
1 Children's Hospital Boston
2 Harvard Medical School
3 Massachusetts Institute of Technology
* To whom correspondence should be addressed. E-mail: horvitz{at}mit.edu.
Submitted on January 28, 2006
Revised on March 16, 2006
Accepted on 2 April 2006
The synthetic multivulva (synMuv) genes negatively regulate Ras-mediated vulval induction in the nematode Caenorhabditis elegans. The synMuv genes define three classes, A, B and C, such that double mutants carrying mutations in genes of any two classes are multivulva. The class B synMuv genes include lin-35, a homolog of the retinoblastoma (Rb) tumor suppressor gene, as well as homologs of genes that function with Rb in transcriptional regulation. We screened for additional synMuv mutations using a strategy different from that of previous synMuv genetic screens. Some of the mutations we recovered affect new synMuv genes. We present criteria for assigning synMuv mutations into different genetic classes. We also describe the molecular characterization of the class B synMuv gene lin-65.
Key Words: Ras, Rb, multivulva, synMuv, vulval development
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