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genetics.105.054684v1
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doi:10.1534/genetics.105.054684
A more recent version of this article appeared on July 1, 2006.
NOTE |
Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting
Patricia J Wittkopp 1*, Belinda K Haerum 1 and Andrew G. Clark 2
1 University of Michigan
2 Cornell University
* To whom correspondence should be addressed. E-mail: wittkopp{at}umich.edu.
Submitted on December 13, 2005
Revised on January 9, 2006
Accepted on 5 May 2006
Parent-of-origin effects create differences in gene expression among genetically identical individuals. Using measurements of allele-specific expression, we demonstrate that previously reported parent-of-origin effects on standing mRNA levels in Drosophila melanogaster are not attributable to genomic imprinting. Offspring from reciprocal crosses exhibit differences in total expression without differences in relative allelic expression, indicating other types of maternal and/or paternal effects alter expression.
Key Words: cis, gene regulation, maternal effect, parental imprinting, paternal effect
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