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doi:10.1534/genetics.105.053389
A more recent version of this article appeared on March 1, 2006.
REGULAR RESEARCH PAPERS |
Involvement of Drosophila Uncoupling Protein 5 in Metabolism and Aging
Adolfo Sanchez-Blanco 1, Yih-Woei C Fridell 1 and Stephen L Helfand 2*
1 University of Connecticut Health Center
2 Brown University
* To whom correspondence should be addressed. E-mail: stephen_helfand{at}brown.edu.
Submitted on November 10, 2005
Revised on December 9, 2005
Accepted on 30 December 2005
A novel uncoupling protein, UCP5, has recently been characterized as a functional mitochondrial uncoupler in Drosophila. Here we demonstrate that UCP5 knock-out (UCP5KO) flies are highly sensitive to starvation stress, a phenotype that can be reversed by ectopic neuronal expression of UCP5. UCP5KO flies live longer than controls on low calorie diets, have a decreased level of fertility, and gain less weight than controls on high calorie diets. However, isolated mitochondria from UCP5KO flies display the same respiration patterns as controls. Furthermore, total ATP levels in both UCP5KO and control flies are comparable. UCP5KO flies have lower body composition of sugars, and during starvation stress their triglyceride reserves are depleted more rapidly than controls. Taken together, these data indicate that UCP5 is important to maintain metabolic homeostasis in the fly. We hypothesize that UCP5 influences hormonal control of metabolism.
Key Words: Drosophila UCP5 knockout, aging, metabolism, mitochondria, mitochondrial uncoupling
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