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doi:10.1534/genetics.105.052985
A more recent version of this article appeared on May 1, 2006.
REGULAR RESEARCH PAPERS |
The Genetic Basis of Postzygotic Reproductive Isolation Between Drosophila santomea and D. yakuba Due to Hybrid Male Sterility
Amanda J. Moehring 1*, Ana Llopart 2, Susannah Elwyn 3, Jerry A Coyne 4 and Trudy F.C. Mackay 5
1 Duke University
2 University of Iowa
3 Harvard Medical School
4 University of Chicago
5 North Carolina State University
* To whom correspondence should be addressed. E-mail: ajmoehring{at}gmail.com.
Submitted on October 31, 2005
Revised on December 9, 2005
Accepted on 17 February 2006
A major unresolved challenge of evolutionary biology is to determine the nature of the allelic variants of "speciation genes": those alleles whose interaction produces inviable or infertile interspecific hybrids but do not reduce fitness in pure species. Here we map quantitative trait loci (QTLs) affecting fertility of male hybrids between D. yakuba and its recently discovered sibling species, D. santomea. We mapped three to four X chromosome QTLs and two autosomal QTLs with large effects on the reduced fertility of D. yakuba and D. santomea backcross males. We observed epistasis between the X-linked QTLs, and also between the X and autosomal QTLs. The X chromosome had a disproportionately large effect on hybrid sterility in both reciprocal backcross hybrids. However, the genetics of hybrid sterility differs between D. yakuba and D. santomea backcross males, both in terms of the magnitude of main effects and in the epistatic interactions. The QTLs affecting hybrid fertility did not co-localize with QTLs affecting sexual isolation in this species pair, but did co-localize with QTLs affecting the marked difference in pigmentation between D. yakuba and D. santomea. These results provide the basis for future high-resolution mapping, and ultimately, molecular cloning, of the interacting genes that contribute to hybrid sterility.
Key Words: QTL mapping, hybrid sterility, reproductive isolation, speciation
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