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Marna D. Yandeau-Nelson
Jin Li
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doi:10.1534/genetics.105.052712
A more recent version of this article appeared on August 1, 2006.
REGULAR RESEARCH PAPERS |
Unequal sister chromatid and homolog recombination at a tandem duplication of the a1 locus in maize
Marna D. Yandeau-Nelson 1, Yiji Xia 2, Jin Li 1, M. Gerald Neuffer 3 and Patrick Schnable 1*
1 Iowa State University
2 Donald Danforth Plant Science Center
3 USDA/ARS/University of Missouri
* To whom correspondence should be addressed. E-mail: schnable{at}iastate.edu.
Submitted on November 11, 2005
Revised on January 3, 2006
Accepted on 31 May 2006
Tandemly arrayed duplicate genes are prevalent. The
maize A1-b haplotype is a tandem duplication that
consists of the components, 
and 
. The
rate of meiotic unequal recombination at A1-b is
nine-fold higher when a homolog is present than when it
is absent (i.e., hemizygote). When a sequence
heterologous homolog is available, 94% of recombinants
(264/281) are generated via recombination with the
homolog rather than with the sister chromatid. In
addition, 83% (220/264) of homolog recombination events
involved rather than . These results
indicate that: 1) the homolog is the preferred template
for unequal recombination, and 2) pairing configurations
between homologs do not occur at random. The choice of
recombination template (i.e., homolog versus sister
chromatid) affects the distribution of recombination
breakpoints within a1. Rates of unequal
recombination at A1-b are similar to the rate of
recombination between non-duplicated a1 alleles.
Unequal recombination is therefore common and is likely
to be responsible for the generation of genetic
variability, even within inbred lines.
Key Words: meiotic recombination, sister chromatid, tandem duplication, unequal crossing over
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