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doi:10.1534/genetics.105.051300
A more recent version of this article appeared on May 1, 2006.
REGULAR RESEARCH PAPERS |
Population genetics of translational robustness
Claus O. Wilke 1* and D. Allan Drummond 2
1 University of Texas at Austin
2 California Institute of Technology
* To whom correspondence should be addressed. E-mail: cwilke{at}mail.utexas.edu.
Submitted on September 21, 2005
Revised on December 1, 2005
Accepted on 15 February 2006
Recent work has shown that expression level is the main predictor of a gene's evolutionary rate, and that more highly expressed genes evolve slower. A possible explanation for this observation is selection for proteins which fold properly despite mistranslation, in short selection for translational robustness. Translational robustness leads to the somewhat paradoxical prediction that highly expressed genes are extremely tolerant to missense substitutions but nevertheless evolve very slowly. Here, we study a simple theoretical model of translational robustness that allows us to gain analytic insight into how this paradoxical behavior arises.
Key Words: evolutionary rate, expression level, neutrality, protein evolution, translation
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