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doi:10.1534/genetics.105.051227
A more recent version of this article appeared on March 1, 2006.
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Pleiotropic quantitative trait loci contribute to population divergence in traits associated with life history variation in Mimulus guttatus
Megan C Hall 1*, Christopher J Basten 2 and John Willis 3
1 North Carolina State University, Duke University
2 Syngenta Biotechnology, Inc.
3 Duke University
* To whom correspondence should be addressed. E-mail: mchall{at}ncsu.edu.
Submitted on September 17, 2005
Revised on October 22, 2005
Accepted on 22 November 2005
Evolutionary biologists seek to understand the genetic basis for multivariate phenotypic divergence. We constructed an F2 mapping population (N = 539) between two distinct populations of Mimulus guttatus. We measured 20 floral, vegetative, and life-history characters on parents, F1 and F2 hybrids in a common garden experiment. We employed multitrait composite interval mapping to determine the number, effect, and degree of pleiotropy in quantitative trait loci (QTLs) affecting divergence in floral, vegetative, and life-history characters. We detected sixteen QTLs affecting floral traits, 7 affecting vegetative traits, and 5 affecting selected floral, vegetative, and life-history traits. Floral and vegetative traits are clearly polygenic. We detected a few major QTLs, with all remaining QTLs of small effect. Most detected QTLs are pleiotropic, implying the evolutionary shift between these annual and perennial populations is constrained. We also compared the genetic architecture controlling floral trait divergence both within (our intraspecific study) and between species, based on a previously published analysis of M. guttatus and M. nasutus. Eleven of our sixteen floral QTLs map to approximately the same location in the interspecific map based on shared, collinear markers, implying there may be a shared genetic basis for floral divergence within and among species of Mimulus.
Key Words: QTL mapping, comparative mapping, complex phenotypes, pleiotropy
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