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genetics.105.051029v1
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doi:10.1534/genetics.105.051029
A more recent version of this article appeared on April 1, 2006.
NOTE |
Saccharomyces cerevisiae polymerase 
functions in mitochondria
Hengshan Zhang 1, Aditi Chatterjee 2 and Keshav K Singh 1*
1 Roswell Park Cancer Institute
2 Johns Hopkins Oncology Center
* To whom correspondence should be addressed. E-mail: keshav.singh{at}roswellpark.org.
Submitted on September 13, 2005
Revised on October 19, 2005
Accepted on 18 January 2006
MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase 
and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase z and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase z and Rev1 proteins function in the mitochondria.
Key Words: Damage Bypass Repair, Error Prone Repair, Polymerase zeta, Rev, Rev3, Rev7, mitochondria