- THIS ARTICLE
- Full Text (Rapid PDF)
-
All Versions of this Article:
genetics.105.050583v1
172/2/1337 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
-
Author home page(s):
Jerome Goudet
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Goudet, J.
- Articles by Buchi, L.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Goudet, J.
- Articles by Buchi, L.
doi:10.1534/genetics.105.050583
A more recent version of this article appeared on February 1, 2006.
REGULAR RESEARCH PAPERS |
The effects of dominance, regular inbreeding and sampling design on QST, an estimator of population differentiation for quantitative traits
Jerome Goudet 1* and Lucie Buchi 1
1 University of Lausanne
* To whom correspondence should be addressed. E-mail: jerome.goudet{at}unil.ch.
Submitted on September 12, 2005
Revised on November 2, 2005
Accepted on 8 November 2005
In order to test whether quantitative traits are under directional or homogenizing selection, it is common practice to compare population differentiation estimates at molecular markers (FST) and quantitative traits (QST). If the trait is neutral and its determinism is additive, then theory predicts that QST=FST, while QST>FST is predicted under directional selection for different local optima, and QST<FST is predicted under homogenizing selection. However, non additive effects can alter these predictions. Here, we investigate the influence of dominance on the relation between QST and FST for neutral traits. Using analytical results and computer simulations, we show that dominance generally deflates QST relative to FST. Under inbreeding, the effect of dominance vanishes, and we show that for selfing species, a better estimate of QST is obtained from selfed families than half-sib families. We also compare several sampling design and found that it is always best to sample many populations (>20) with few families (5) rather than few populations with many families. Providing that estimates of QST are derived from individuals originating from many populations, we conclude that the pattern QST>FST, and hence the inference of directional selection for different local optima, is robust to the effect of non additive gene actions.
Key Words: computer simulations, genetic determinism, neutral models, population differentiation, quantitative genetics
This article has been cited by other articles:
 |
|
 |
|
  J. S. Escobar, A. Nicot, and P. David The Different Sources of Variation in Inbreeding Depression, Heterosis and Outbreeding Depression in a Metapopulation of Physa acuta Genetics, November 1, 2008; 180(3): 1593 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Miller, B. P. Wood, and M. B. Hamilton FST and QST Under Neutrality Genetics, October 1, 2008; 180(2): 1023 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Jolivet and G. Bernasconi Molecular and Quantitative Genetic Differentiation in European Populations of Silene latifolia (Caryophyllaceae) Ann. Bot., July 1, 2007; 100(1): 119 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Goudet and G. Martin Under Neutrality, QST <= FST When There Is Dominance in an Island Model Genetics, June 1, 2007; 176(2): 1371 - 1374. [Full Text] [PDF]
|
|
|
|
|
|
C. Lopez-Fanjul, A. Fernandez, and M. A. Toro The Effect of Dominance on the Use of the QST - FST Contrast to Detect Natural Selection on Quantitative Traits Genetics, May 1, 2007; 176(1): 725 - 727. [Full Text] [PDF]
|
|