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doi:10.1534/genetics.105.050567
A more recent version of this article appeared on February 1, 2006.
REGULAR RESEARCH PAPERS |
Diverse mitotic and interphase functions of condensins in Drosophila
Neville Cobbe 1, Ellada Savvidou 1 and Margarete M. S. Heck 1*
1 Wellcome Trust Centre for Cell Biology, University of Edinburgh
* To whom correspondence should be addressed. E-mail: margarete.heck{at}ed.ac.uk.
Submitted on September 2, 2005
Revised on October 14, 2005
Accepted on 14 October 2005
The condensin complex has been implicated in the higher order organization of mitotic chromosomes in a host of model eukaryotes, from yeasts to flies and vertebrates. Although chromosomes appear paradoxically to condense in condensin mutants, chromatids are not properly resolved, resulting in chromosome segregation defects during anaphase. We have examined the role of different condensin complex components in interphase chromatin function, by examining the effects of various condensin mutations on position effect variegation in Drosophila melanogaster. Surprisingly, most mutations affecting condensin proteins were often found to result in strong enhancement of variegation, in contrast to what might be expected for proteins believed to compact the genome. This suggests that the role of these proteins in interphase may differ from their expected roles in mitosis.
Key Words: SMC, condensin, epigenetics, interphase, mitosis
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