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Genetics. Published Articles Ahead of Print: December 16, 2005, Copyright © 2005
doi:10.1534/genetics.105.050336

A more recent version of this article appeared on March 1, 2006.
Originally published as Genetics Published Articles Ahead of Print on December 15, 2005.
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REGULAR RESEARCH PAPERS

Novel melanogaster subgroup genes identified from Drosophila yakuba and D. erecta accessory gland ESTs

David Begun 1*, Heather Lindfors 1, Melissa Thompson 1 and Alisha Holloway 1

1 UC-Davis

* To whom correspondence should be addressed. E-mail: djbegun{at}ucdavis.edu.

Submitted on August 31, 2005
Revised on October 5, 2005
Accepted on 22 November 2005


  Abstract
The fraction of the genome associated with male reproduction in Drosophila may be unusually dynamic. For example, male reproduction-related genes show higher-than-average rates of protein divergence and gene expression evolution compared to most Drosophila genes. Drosophila male reproduction may also be enriched for novel genetic functions. Our earlier work, based on accessory gland protein genes (Acps) in D. simulans and D. melanogaster, suggested that melanogaster subgroup Acps may be lost and/or gained on a relatively rapid timescale. Here we investigate this possibility more thoroughly through description of the accessory gland transcriptome in two melanogaster subgroup species, D. yakuba and D. erecta. A genomic analysis of previously unknown genes isolated from cDNA libraries of these species revealed several cases of genes present in one or both species, yet absent from ingroup and outgroup species. We found no evidence that these novel genes are attributable primarily to duplication and divergence, which suggests the possibility that Acps or other genes coding for small, secreted proteins may originate from ancestrally non-coding DNA.

Key Words: Acp, natural selection, novel genes, orphans, signal sequence




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