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doi:10.1534/genetics.105.049973
A more recent version of this article appeared on February 1, 2006.
REGULAR RESEARCH PAPERS |
A scan of molecular variation leads to the narrow localization of a selective sweep affecting both Afrotropical and cosmopolitan populations of Drosophila melanogaster
John E Pool 1*, Vanessa Bauer DuMont 1, Jacob L Mueller 1 and Charles F Aquadro 1
1 Cornell University
* To whom correspondence should be addressed. E-mail: jep36{at}cornell.edu.
Submitted on August 23, 2005
Revised on October 30, 2005
Accepted on 10 November 2005
Drosophila melanogaster originated in tropical Africa but has achieved a cosmopolitan distribution in association with human habitation. Cosmopolitan populations of D. melanogaster are known to have reduced genetic variation, particularly on the X chromosome. However, the relative importance of population bottlenecks and selective sweeps in explaining this reduction is uncertain. We surveyed variation at 31 microsatellites across a 330 kilobase section of the X chromosome located between the white and kirre genes. Two linked clusters of loci were observed with reduced variation and a skew toward rare alleles in both an Ecuador and a Zimbabwe population sample. Examining Zimbabwe DNA sequence polymorphism within one of these regions allowed us to localize a selective sweep to a 361 bp window within the 5' regulatory region of the roughest gene, with one nucleotide substitution representing the best candidate for the target of selection. Estimates of sweep age suggested that this fixation event occurred prior to the expansion of D. melanogaster from sub-Saharan Africa. For both putative sweep regions in our data set, cosmpolitan populations showed wider footprints of selection compared to Zimbabwe. This pattern appears consistent with the demographic amplification of pre-existing sweep signals due to one or more population bottlenecks.
Key Words: DNA sequence variability, Drosophila melanogaster, Microsatellite variabililty, Selective sweep, roughest
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