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doi:10.1534/genetics.105.049494
A more recent version of this article appeared on August 1, 2006.
REGULAR RESEARCH PAPERS |
Influence of Mom and Dad: Quantitative Genetic Models for Maternal Effects and Imprinting
Anna W. Santure 1* and Hamish G. Spencer 1
1 University of Otago
* To whom correspondence should be addressed. E-mail: asanture{at}gmail.com.
Submitted on August 11, 2005
Revised on October 10, 2005
Accepted on 29 May 2006
The expression of an imprinted gene is dependent on the sex of the parent it was inherited from, and as a result reciprocal heterozygotes may display different phenotypes. In contrast, maternal genetic terms arise when the phenotype of an offspring is influenced by the genotype of its mother beyond the direct inheritance of alleles. Both maternal effects and imprinting may contribute to resemblance between offspring of the same mother. We demonstrate that two standard quantitative genetic models for deriving breeding values, population variances and covariances between relatives are not equivalent when maternal genetic effects and imprinting are acting. Maternal and imprinting effects introduce both sex-dependent and generation-dependent effects that result in differences in the way additive and dominance effects are defined for the two approaches. We use a simple example to demonstrate that imprinting and maternal genetic effects both add extra terms to covariances between relatives, and that model misspecification may over- or under-estimate true covariances or lead to extremely variable parameter estimation. Thus, an understanding of various forms of parental effects is essential in correctly estimating quantitative genetic variance components.
Key Words: correlations between relatives, genetic correlation, genetic variance, quantitative genetics
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