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doi:10.1534/genetics.105.048520
A more recent version of this article appeared on March 1, 2006.
REGULAR RESEARCH PAPERS |
Quantitative Trait Loci with Age-Specific Effects on Fecundity in Drosophila melanogaster
Jeff Leips 1*, Paul Gilligan 2 and Trudy F. C. Mackay 2
1 University of Maryland Baltimore County
2 North Carolina State University
* To whom correspondence should be addressed. E-mail: leips{at}umbc.edu.
Submitted on July 19, 2005
Revised on September 19, 2005
Accepted on 19 October 2005
ABSTRACT Life history theory and evolutionary theories of aging assume the existence of alleles with age-specific effects on fitness. While various studies have documented age-related changes in the genetic contribution to the variation in fitness components we know very little about the underlying genetic architecture of such changes. We used a set of recombinant inbred lines to map and characterize the effects of quantitative trait loci (QTL) affecting fecundity of Drosophila melanogaster females at one and four weeks of age. We identified one QTL on the second chromosome and one or two QTL affecting fecundity on the third chromosome, but these QTL affected fecundity only at one week of age. There was more genetic variation for fecundity at four weeks than at one week and there was no significant genetic correlation between early and late age fecundity. This suggests that different loci contribute to the variation in fecundity as the organism ages. Our data provide support for the mutation accumulation theory of aging as applied to reproductive senescence. Comparing the results from this study with our previous work on life span QTL we also find evidence that antagonistic pleiotropy may contribute to the genetic basis of reproductive senescence as well.
Key Words: QTL, aging, genetic architecture, life history traits, reproduction
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