- THIS ARTICLE
- Full Text (Rapid PDF)
-
All Versions of this Article:
genetics.105.048207v1
172/1/171 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
-
Author home page(s):
Asher D Cutter
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Cutter, A. D
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Cutter, A. D
doi:10.1534/genetics.105.048207
A more recent version of this article appeared on January 1, 2006.
REGULAR RESEARCH PAPERS |
Nucleotide polymorphism and linkage disequilibrium in wild populations of the partial selfer Caenorhabditis elegans
Asher D Cutter 1*
1 University of Edinburgh
* To whom correspondence should be addressed. E-mail: asher.cutter{at}ed.ac.uk.
Submitted on July 13, 2005
Revised on August 12, 2005
Accepted on 28 September 2005
An understanding of the relative contributions of different evolutionary forces on an organism's genome requires an accurate description of the patterns of genetic variation within and between natural populations. To this end, I report a survey of nucleotide polymorphism in six loci from 118 strains of the nematode Caenorhabditis elegans. These strains derive from wild populations of several regions within France, Germany, and new localities in Scotland, in addition to stock center isolates. Overall levels of silent-site diversity are low within and between populations of this self-fertile species, averaging 0.2% in European samples and 0.3% worldwide. Population structure is present despite a lack of association of sequences with geography, and migration appears to occur at all geographic scales. Linkage disequilibrium is extensive in the C. elegans genome, even extending between chromosomes. Nevertheless, recombination is clearly present in the pattern of polymorphisms, indicating that outcrossing is an infrequent, but important, feature in this species ancestry. The range of outcrossing rates consistent with the data is inferred from linkage disequilibrium, using "scattered" samples representing the collecting phase of the coalescent process in a subdivided population. I propose that genetic variation in this species is largely shaped by population subdivision due to self-fertilization coupled with long- and short-range migration between subpopulations.
Key Words: Caenorhabditis elegans, genetic variation, hermaphrodite, linkage disequilibrium, self-fertilization
This article has been cited by other articles:
 |
|
 |
|
  J. H. Thomas Genome evolution in Caenorhabditis Brief Funct Genomic Proteomic, June 23, 2008; (2008) eln022v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Cutter, J. D. Wasmuth, and N. L. Washington Patterns of Molecular Evolution in Caenorhabditis Preclude Ancient Origins of Selfing Genetics, April 1, 2008; 178(4): 2093 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Cutter Divergence Times in Caenorhabditis and Drosophila Inferred from Direct Estimates of the Neutral Mutation Rate Mol. Biol. Evol., April 1, 2008; 25(4): 778 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Cutter Multilocus Patterns of Polymorphism and Selection Across the X Chromosome of Caenorhabditis remanei Genetics, March 1, 2008; 178(3): 1661 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Seidel, M. V. Rockman, and L. Kruglyak Widespread Genetic Incompatibility in C. Elegans Maintained by Balancing Selection Science, February 1, 2008; 319(5863): 589 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barriere and M.-A. Felix Temporal Dynamics and Linkage Disequilibrium in Natural Caenorhabditis elegans Populations Genetics, June 1, 2007; 176(2): 999 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Chasnov, W. K. So, C. M. Chan, and K. L. Chow The species, sex, and stage specificity of a Caenorhabditis sex pheromone PNAS, April 17, 2007; 104(16): 6730 - 6735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Loewe and B. Charlesworth Background Selection in Single Genes May Explain Patterns of Codon Bias Genetics, March 1, 2007; 175(3): 1381 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. LaMunyon, O. Bouban, and A. D. Cutter Postcopulatory Sexual Selection Reduces Genetic Diversity in Experimental Populations of Caenorhabditis elegans J. Hered., January 1, 2007; 98(1): 67 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Cutter, S. E. Baird, and D. Charlesworth High Nucleotide Polymorphism and Rapid Decay of Linkage Disequilibrium in Wild Populations of Caenorhabditis remanei Genetics, October 1, 2006; 174(2): 901 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Cutter, M.-A. Felix, A. Barriere, and D. Charlesworth Patterns of Nucleotide Polymorphism Distinguish Temperate and Tropical Wild Isolates of Caenorhabditis briggsae Genetics, August 1, 2006; 173(4): 2021 - 2031. [Abstract] [Full Text] [PDF]
|
|