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doi:10.1534/genetics.105.046169
A more recent version of this article appeared on January 1, 2006.
REGULAR RESEARCH PAPERS |
Fine Mapping and physical characterization of two linked QTLs Affecting Milk Fat Yield in Dairy Cattle on BTA26
Mathieu Gautier 1*, Rosa Roy Barcelona 1, Sebastien Fritz 2, Cecile Grohs 1, Tom Druet 1, Didier Boichard 1, Andre Eggen 1 and Theo Meuwissen 3
1 INRA
2 UNCEIA
3 IHF NLH
* To whom correspondence should be addressed. E-mail: mathieu.gautier{at}jouy.inra.fr.
Submitted on May 27, 2005
Revised on July 11, 2005
Accepted on 12 September 2005
Previously, a highly significant QTL affecting Fat Yield and Protein Yield and mapped to bovine BTA26 chromosome has been reported to segregate in the French Holstein cattle population. In order to confirm and refine the location of this QTL, the original detection experiment was extended by adding 12 new families and genotyping 25 additional microsatellite markers (including 11 newly developed markers). Data were then analysed by an approach combining both linkage and linkage disequilibrium information making it possible to identify two linked QTLs separated by 20 cM corresponding to approximately 29 Mb. The presence of a QTL affecting Protein Yield was confirmed but its position was found to be more telomeric than the two ones underlying Fat Yield. Each identified QTLs affecting Milk Fat Yield was physically mapped within a segment estimated less than 500 kb. Two strong functional candidate genes involved respectively in fatty acid metabolism and membrane permeability were found to be localised within this segment while other functional candidate genes were discarded. A haplotype comprising the favourable allele at each QTL position appears to be overrepresented in the Artificial Insemination bull population.
Key Words: Fat Yield, QTL mapping, cattle, linkage disequilibrium, physical map
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