- THIS ARTICLE
- Full Text (Rapid PDF)
-
All Versions of this Article:
genetics.105.046110v1
172/2/1369 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Douville, J.
- Articles by Ramotar, D.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Douville, J.
- Articles by Ramotar, D.
doi:10.1534/genetics.105.046110
A more recent version of this article appeared on February 1, 2006.
REGULAR RESEARCH PAPERS |
The Saccharomyces Cerevisiae Phosphatase Activator YPTPA1/RRD1 is Required to Modulate Gene Expression in Response to Rapamycin Exposure
Julie Douville 1, Jocelyn David 1, Karine Lemieux 2, Luc Gaudreau 2 and Dindial Ramotar 1*
1 University of Montreal
2 Université de Sherbrooke
* To whom correspondence should be addressed. E-mail: dramotar.hmr{at}ssss.gouv.qc.ca.
Submitted on May 25, 2005
Revised on September 2, 2005
Accepted on 12 November 2005
We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin, and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II leading to transcription of critical genes that sustain growth.
Key Words: RNA pol II, gene expression, phosphatase activator, proteolysis, yeast
This article has been cited by other articles:
 |
|
 |
|
  M. Shimanuki, S.-Y. Chung, Y. Chikashige, Y. Kawasaki, L. Uehara, C. Tsutsumi, M. Hatanaka, Y. Hiraoka, K. Nagao, and M. Yanagida Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombe Genes Cells, May 1, 2007; 12(5): 677 - 692. [Abstract] [Full Text] [PDF]
|
|