Genetics. Published Articles Ahead of Print: July 5, 2005, Copyright © 2005
doi:10.1534/genetics.105.046060


A more recent version of this article appeared on October 1, 2005.

NOTE

Transcriptional Compensation for Gene Loss Plays a Minor Role in Maintaining Genetic Robustness in Saccharomyces cerevisiae

Sharyl L. Wong 1 and Frederick P. Roth 1*

1 Harvard Medical School

* To whom correspondence should be addressed. E-mail: froth{at}hms.harvard.edu.

Submitted on May 6, 2005
Revised on June 21, 2005
Accepted on 21 June 2005


Abstract

If a gene is mutated and its function lost, are compensatory genes upregulated? We investigated whether genes are transcriptionally upregulated when their synthetic sick or lethal (SSL) partners are lost. We identified several new examples, however, remarkably few SSL pairs exhibited this phenomenon, suggesting that transcriptional compensation by SSL partners is a rare mechanism for maintaining genetic robustness.

Key Words: genetic interaction, genetics, genomics, robustness, synthetic lethal




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