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doi:10.1534/genetics.105.045930
A more recent version of this article appeared on November 1, 2005.
NOTE |
A statistical multi-probe model for analyzing cis- and trans-genes in genetical genomics experiments with short-oligonucleotide arrays
Rudi Alberts 1*, Peter Terpstra 1, Leonid V. Bystrykh 1, Gerald de Haan 1 and Ritsert C. Jansen 1
1 University of Groningen
* To whom correspondence should be addressed. E-mail: r.alberts{at}rug.nl.
Submitted on May 26, 2005
Revised on June 3, 2005
Accepted on 15 July 2005
Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help separating "true" differential mRNA expression from "ghost" effects caused by polymorphisms, misdesigned probes and batch effects. It can also help detecting alternative splicing, start or termination.
Key Words: genetical genomics, quantitative trait loci (QTL), short-oligonucleotide arrays, statistics, summary methods
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