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doi:10.1534/genetics.105.045922
A more recent version of this article appeared on January 1, 2006.
REGULAR RESEARCH PAPERS |
Lysis Timing and Bacteriophage Fitness
Ing-Nang Wang 1*
1 State University of New York at Albany
* To whom correspondence should be addressed. E-mail: ingnang{at}albany.edu.
Submitted on May 20, 2005
Revised on July 21, 2005
Accepted on 29 September 2005
The effect of lysis timing on bacteriophage (phage) fitness has received little theoretical or experimental attention. Previously, the impact of lysis timing on phage fitness was studied using a theoretical model based on the marginal value theorem from the optimal foraging theory. An implicit conclusion of the model is that, for any combination of host quantity and quality, there would exist an optimal time to lyse the host so that the phage fitness would be the highest. To test the prediction, an array of isogenic 
phages that only differ in their lysis times was constructed. For each phage strain, the lysis time, burst size, and fitness (growth rate) were determined. The result showed that there is a positive linear relationship between lysis time and burst size. Moreover, the strain with an intermediate lysis time has the highest fitness, indicating the existence of an optimal lysis time. A mathematical model is also constructed to describe the population dynamics of phage infection. Computer simulations using parameter values derived from phage infection also showed an optimal lysis time. However, both the optimum and the fitness are different from the experimental result. The evolution of phage lysis timing is discussed from the perspectives of multiple infection and life history trait evolution.
Key Words: evolution, life history traits, lysis, optimality, phage
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