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doi:10.1534/genetics.105.045526
A more recent version of this article appeared on October 1, 2005.
Article |
Intermediate mutation frequencies favor evolution of multidrug resistance
Erick Denamur 1, Olivier Tenaillon 1, Catherine Deschamps 2, David Skurnik 3, Esthel Ronco 4, Jean-Louis Gaillard 4, Bertrand Picard 5, Catherine Branger 2 and Ivan Matic 6*
1 INSERM U722 - Université Paris 7
2 Hôpital Louis Mourier
3 Hôpital Bichat
4 Hôpital Poincaré
5 Hôpital Avicenne
6 INSERM U571 Faculte de medecine- Necker
* To whom correspondence should be addressed. E-mail: matic{at}necker.fr.
Submitted on May 11, 2005
Revised on May 20, 2005
Accepted on 20 May 2005
Studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.
Key Words: bacteria, drug resistance, evolution, mutagenesis, mutators
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