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doi:10.1534/genetics.105.042051
A more recent version of this article appeared on September 1, 2005.
REGULAR RESEARCH PAPERS |
A genetic linkage map for the tiger pufferfish, Takifugu rubripes
Wataru Kai 1, Kiyoshi Kikuchi 1*, Masashi Fujita 1, Hiroaki Suetake 1, Atushi Fujiwara 2, Yasutoshi Yoshiura 2, Mitsuru Ototake 2, Byrappa Venkatesh 3, Kadoo Miyaki 4 and Yuzuru Suzuki 1
1 Fisheries Laboratory, The University of Tokyo
2 National Research Institute of Aquaculture, Fisheries Research Agency
3 Institute of Molecular and Cell Biology
4 Nagasaki Prefectural Institute of Fisheries
* To whom correspondence should be addressed. E-mail: akikuchi{at}mail.ecc.u-tokyo.ac.jp.
Submitted on February 15, 2005
Revised on April 1, 2005
Accepted on 13 June 2005
The compact genome of the tiger pufferfish, Takifugu rubripes, (fugu) has been sequenced to the "draft" level and annotated to identify all the genes. However, the assembly of the draft genome sequence is highly fragmented due to the lack of a genetic or a physical map. To determine the long-range linkage relationship of the sequences, we have constructed the first genetic linkage map for fugu. The maps for the male and female spanning 697.1 and 1,213.5 cM, respectively, were arranged into 22 linkage groups by markers heterozygous in both parents. The resulting map consists of 200 microsatellite loci physically linked to genome sequences spanning about 39 Mb in total. Comparisons of the genome maps of fugu, other teleosts and mammals suggest that syntenic relationship is more conserved in the teleost lineage than in the mammalian lineage. Map comparisons also show a pufferfish lineage specific rearrangement of the genome resulting in co-localization of two Hox gene clusters in one linkage group. This map provides a foundation for development of a complete physical map, a basis for comparison of long-range linkage of genes with other vertebrates, and a resource for mapping loci responsible for phenotypic differences between Takifugu species.
Key Words: Hox gene, comparative genomics, evolution, genetic linkage map, pufferfish
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