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doi:10.1534/genetics.105.041319
A more recent version of this article appeared on August 1, 2005.
REGULAR RESEARCH PAPERS |
Genomic mapping of direct and correlated responses to long-term selection for rapid weight gain in mice
Mark Allan 1, Gene Eisen 2 and Daniel Pomp 3*
1 USDA - MARC
2 NC State University
3 University of Nebraska
* To whom correspondence should be addressed. E-mail: dpomp{at}unl.edu.
Submitted on February 1, 2005
Revised on March 15, 2005
Accepted on 29 April 2005
Understanding the genetic architecture of traits such as growth, body composition and energy balance has become a primary focus for biomedical and agricultural research. The objective of this study was to map QTL in a large F2 (n=1181) population resulting from an intercross between the M16 and ICR lines of mice. The M16 line, developed by long-term selection for 3 to 6 wk weight gain, is larger, heavier, fatter, hyperphagic, and diabetic relative to its randomly selected control line of ICR origin. The F2 population was phenotyped for growth and energy intake at weekly intervals from 4 to 8 weeks of age and for body composition and plasma levels of insulin, leptin, TNFá, IL-6 and glucose at 8 weeks, and was genotyped for 80 microsatellite markers. Since the F2 was a cross between a selection line and its unselected control, the QTL identified likely represent genes that contributed to direct and correlated responses to long-term selection for rapid growth rate. Across all traits measured, 95 QTL were identified, likely representing 19 unique regions on 13 chromosomes. Four chromosomes (2, 6, 11, 17) harbored loci contributing disproportionately to selection response. Several QTL were identified demonstrating differential regulation of regional adipose deposition and age-dependent regulation of growth and energy consumption.
Key Words: Body Weight, Energy Balance, Obesity, QTL, Selection Response
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