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Genetics. Published Articles Ahead of Print: March 31, 2005, Copyright © 2005
doi:10.1534/genetics.105.041277
doi:10.1534/genetics.105.041277
A more recent version of this article appeared on June 1, 2005.
NOTE |
Mutations in Snail family genes enhance craniosynostosis of Twist1 haploinsufficient mice: implications for Saethre-Chotzen syndrome
Kathleen F. Oram 1 and Thomas Gridley 1*
1 Jackson Laboratory
* To whom correspondence should be addressed. E-mail: gridley{at}jax.org.
Submitted on January 28, 2005
Revised on February 15, 2005
Accepted on 15 February 2005
Abstract
In Drosophila, mutations in the Twist gene interact with mutations in the Snail gene. We show that the mouse Twist1 mutation interacts with Snai1 and Snai2 mutations to enhance aberrant cranial suture fusion, demonstrating that genetic interactions between genes of the Twist and Snail families have been conserved during evolution.
Key Words: Snail, Twist, enhancers, haploinsufficiency
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