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doi:10.1534/genetics.105.040782
A more recent version of this article appeared on November 1, 2005.
REGULAR RESEARCH PAPERS |
Extent and consistency across generations of linkage disequilibrium in commercial chicken breeding populations
Eliyahu M Heifetz 1, Janet E Fulton 2, Neil O'Sullivan 2, Hong-Hua Zhao 1, Jack C. M. Dekkers 1 and Morris Soller 3*
1 Iowa State University
2 Hy-Line International
3 The Hebrew Institute of Jerusalem
* To whom correspondence should be addressed. E-mail: soller{at}vms.huji.ac.il.
Submitted on April 19, 2005
Revised on June 13, 2005
Accepted on 2 August 2005
Recent studies report a surprisingly high degree of marker to marker linkage disequilibrium (LD) in ruminant livestock populations. This has important implications for QTL mapping and marker assisted selection. The present study evaluated LD between microsatellite markers in a number of breeding populations of layer chickens using the standardized chi-square (
2') measure. The results show appreciable LD among markers separated by up to 5 cM, decreasing rapidly with increased separation between markers. The LD within 5 cM was strongly conserved across generations and differed among chromosomal regions. Using marker to marker LD as an indication for marker-QTL LD, a genome scan of markers spaced two cM apart at moderate power would have good chances of uncovering most QTL segregating in these populations. However, of markers showing significant trait associations, only 57% are expected to be within five cM of the responsible QTL, the remainder will be up to 20 cM away. Thus, high resolution LD mapping of QTL will require dense marker genotyping across the region of interest to allow for interval mapping of the QTL.
Key Words: Linkage disequilibrium, QTL mapping, chicken
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