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doi:10.1534/genetics.105.040741
A more recent version of this article appeared on July 1, 2005.
REGULAR RESEARCH PAPERS |
Epistasis and the adaptability of an RNA virus
Rafael Sanjuán 1, José M. Cuevas 1, Andrés Moya 1 and Santiago F. Elena 2*
1 Universitat de València
2 Consejo Superior de Investigaciones Científicas
* To whom correspondence should be addressed. E-mail: sfelena{at}ibmcp.upv.es.
Submitted on January 11, 2005
Revised on March 8, 2005
Accepted on 29 March 2005
We have explored the patterns of fitness recovery in vesicular stomatitis RNA virus. We show that, in our experimental setting, reversions to the wild type genotype were rare and fitness recovery was at least partially driven by compensatory mutations. We compared compensatory adaptation for genotypes carrying (1) mutations with varying deleterious fitness effects, (2) one or two deleterious mutations, and (3) pairs of mutations showing differences in the strength and sign of epistasis. In all cases, we found that the rate of fitness recovery and the proportion of reversions were positively affected by population size. Additionally, we observed that mutations with large fitness effect were always compensated faster than mutations with small fitness effect. Similarly, compensatory evolution was faster for genotypes carrying single deleterious mutation than for those carrying pairs of mutations. Finally, for genotypes carrying two deleterious mutations, we found evidences for a negative correlation between the epistastic effect and the rate of compensatory evolution.
Key Words: compensatory evolution, epistasis, experimental evolution, rugged adaptive landscapes, viral evolution
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