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doi:10.1534/genetics.104.040253
A more recent version of this article appeared on June 1, 2005.
REGULAR RESEARCH PAPERS |
Dynein Promotes Achiasmate Segregation in Schizosaccharomyces pombe
Luther Davis 1 and Gerald R. Smith 1*
1 Fred Hutchinson Cancer Research Center
* To whom correspondence should be addressed. E-mail: gsmith{at}fhcrc.org.
Submitted on December 21, 2004
Revised on January 25, 2005
Accepted on 15 February 2005
Most organisms use crossovers (chiasmata) to maintain physical connections between homologous chromosomes that ensure their proper segregation at the first meiotic division. The fission yeast Schizosaccharomyces pombe has a residual ability to segregate homologous chromosomes properly in the absence of meiotic recombination (achiasmate segregation). Using cytologically tagged chromosomes, we established a role for the microtubule motor dynein in meiotic chromosome segregation. Dhc1, the motor subunit of dynein, was required for chromosome segregation in both the presence and absence of recombination. Dlc1, a member of the Tctex-1 dynein light-chain family, preferentially affected the segregation of achiasmate chromosomes. Dlc1 is the first identified protein, outside Drosophila, that preferentially affects achiasmate chromosome segregation. We discuss possible roles of the dynein motor in this process.
Key Words: achiasmate, chromosome segregation, dynein, meiosis, recombination
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