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doi:10.1534/genetics.104.039735
A more recent version of this article appeared on April 1, 2005.
REGULAR RESEARCH PAPERS |
RacGap50C negatively regulates Wingless pathway activity during Drosophila embryonic development
Whitney M. Jones 1 and Amy Bejsovec 1*
1 Duke University
* To whom correspondence should be addressed. E-mail: bejsovec{at}duke.edu.
Submitted on December 14, 2004
Revised on December 29, 2004
Accepted on 29 December 2004
The Wingless(Wg)/Wnt signal transduction pathway directs a variety of cell fate decisions in developing animal embryos. Despite the identification of many Wg pathway components to date, it is still not clear how these elements work together to generate cellular identities. In the ventral epidermis of Drosophila embryos, Wg specifies cells to secrete a characteristic pattern of denticles and naked cuticle that decorate the larval cuticle at the end of embryonic development. We have used the Drosophila ventral epidermis as our assay system in a series of genetic screens to identify new components involved in Wg signaling. Two mutant lines that modify wg-mediated epidermal patterning represent the first loss of function mutations in the RacGap50C gene. These mutations on their own cause increased stabilization of Armadillo and cuticle pattern disruptions that include replacement of ventral denticles with naked cuticle, which suggest that the mutant embryos suffer from ectopic Wg pathway activation. In addition, RacGap50C mutations interact genetically with naked cuticle and Axin, known negative regulators of the Wg pathway. These phenotypes suggest that the RacGap50C gene product participates in the negative regulation of Wg pathway activity.
Key Words: Drosophila epidermal patterning, RacGap50C, Wingless, signal transduction
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