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doi:10.1534/genetics.104.039073
A more recent version of this article appeared on June 1, 2005.
REGULAR RESEARCH PAPERS |
The program of sex chromosome pairing in meiosis is highly conserved across marsupial species: implications for sex chromosome evolution
Jesús Page 1, Soledad Berríos 2, María Teresa Parra 3, Alberto Viera 1, José Ángel Suja 1, Ignacio Prieto 4, José Luis Barbero 4, Julio S Rufas 1 and Raúl Fernández-Donoso 2*
1 Universidad Autónoma de Madrid
2 Universidad de Chile
3 Universidad Autónoma de Madrid
4 Centro Nacional de Biotecnología
* To whom correspondence should be addressed. E-mail: rfernand{at}med.uchile.cl.
Submitted on December 1, 2004
Revised on January 25, 2005
Accepted on 25 January 2005
Marsupials present a series of genetic and chromosomal features that are highly conserved in very distant species. One of these features is the absence of a homologous region between X and Y chromosomes. According to this genetic differentiation, sex chromosomes do not synapse during the first meiotic prophase in males, and a special structure, the dense plate, maintains sex chromosome association. In this report we present results on the process of meiotic sex chromosome pairing obtained in three different species, Thylamys elegans, Dromiciops gliroides and Rhyncholestes raphanurus, representing the three Orders of American marsupials. We have investigated the relationships between the axial structures organized along sex chromosomes and the formation of the dense plate. We found that in the three species the dense plate arise as a modification of sex chromosomal axial elements, but without the involvement of other meiotic axial structures, such as the cohesin axis. Considering the phylogenetic relationships between the marsupials studied here, our data reinforce the idea that the dense plate emerged early in marsupial evolution as an efficient mechanism to ensure the association of the non-homologous sex chromosomes. This situation could have influenced the further evolution of sex chromosomes in marsupials.
Key Words: cohesins, marsupials, meiosis, sex chromosomes, synaptonemal complex
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