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doi:10.1534/genetics.104.037333
A more recent version of this article appeared on May 1, 2005.
NOTE |
Intron size and exon evolution in Drosophila
Gabriel Marais 1, Pierre Nouvellet 2, Peter D Keightley 3 and Brian Charlesworth 3*
1 University of Lyon
2 University of Oxford
3 University of Edinburgh
* To whom correspondence should be addressed. E-mail: brian.charlesworth{at}ed.ac.uk.
Submitted on October 8, 2004
Revised on December 21, 2004
Accepted on 28 January 2005
We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints.
Key Words: Drosophila, Gene expression, Intron size, Protein sequence evolution
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