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doi:10.1534/genetics.104.036483
A more recent version of this article appeared on June 1, 2005.
REGULAR RESEARCH PAPERS |
A high frequency null mutant of an odorant-binding protein gene, Obp57e, in Drosophila melanogaster
Aya Takahashi 1* and Toshiyuki Takano-Shimizu 1
1 National Institute of Genetics
* To whom correspondence should be addressed. E-mail: atakahas{at}lab.nig.ac.jp.
Submitted on October 7, 2004
Revised on November 19, 2004
Accepted on 21 February 2005
We have found a null mutant of an odorant-binding protein, Obp57e, in Drosophila melanogaster. This frameshift mutation, which is a 10 bp deletion in the coding region, is at a high frequency in the Kyoto population, and is also present in Taiwan and Africa. We have sequenced a 1.5kb region including the tandemly duplicated gene, Obp57d, from 16 inbred lines sampled in Kyoto, Japan. The analyses showed a peak of nucleotide diversity and strong linkage disequilibrium around this mutation. This pattern suggests an elevated mutation rate or an influence of balancing selection in this region. The level of nucleotide divergence between D. melanogaster and D. simulans does not support the former possibility. Thus, this presence/absence polymorphism may be due to balancing selection, which takes advantage of the relatively weak functional constraint in members of a large gene family. In addition, the Obp57d gene region showed an excess of high frequency derived mutants that is consistent with a pattern predicted under positive natural selection.
Key Words: Obp57e, Drosophila, Odorant-binding protein, balancing selection, null mutation
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