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doi:10.1534/genetics.104.035766
A more recent version of this article appeared on April 1, 2005.
REGULAR RESEARCH PAPERS |
Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster
Ian Michael Dworkin 1*, Arnar Palsson 2 and Greg Gibson 1
1 North Carolina State University
2 University of Chicago
* To whom correspondence should be addressed. E-mail: i_dworkin{at}ncsu.edu.
Submitted on September 1, 2004
Revised on December 15, 2004
Accepted on 1 January 2005
Linkage disequilibrium mapping has been used extensively in medical and evolutionary genetics to map causal polymorphisms within genes associated with disease status or phenotypic variation for a trait. However, the initial findings of most non-human studies have not been replicated in subsequent studies, due in part to false-positives, as well as additional factors that can render true positives un-replicable. These factors may be more severe when the initial study is performed using an experimental population of organisms reared under controlled lab conditions. We demonstrate that despite considerable phenotypic differences for wing-shape between a lab-reared experimental population, and a wild-caught cohort of Drosophila melanogaster, an association between a putative regulatory polymorphism in Egfr and wing-shape can be replicated. These results will be discussed both within the framework of future association mapping studies, and within the context of the evolutionary dynamics of alleles in populations.
Key Words: Egfr, association mapping, geometric morphometrics, wing-shape
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