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Don Flick
Karen H. Fleming
Ryan C. Jochim
Barry J. Beaty
William C. Black IV
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doi:10.1534/genetics.104.035634
A more recent version of this article appeared on May 1, 2005.
REGULAR RESEARCH PAPERS |
Quantitative Trait Loci that Control Dengue-2 Virus Dissemination In the Mosquito Aedes aegypti
Kristine E. Bennett 1, Don Flick 2, Karen H. Fleming 2, Ryan C. Jochim 2, Barry J. Beaty 2 and William C. Black IV 2*
1 Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, CDC
2 Department of Microbiology, Immunology and Pathology, Colorado State University
* To whom correspondence should be addressed. E-mail: wcb4{at}lamar.colostate.edu.
Submitted on August 30, 2004
Revised on December 15, 2004
Accepted on 30 January 2005
The mosquito Aedes aegypti is the most important vector of yellow fever and dengue fever flaviviruses. Aedes aegypti eradication campaigns have not been sustainable and there are no effective vaccines for dengue viruses. Alternative control strategies may depend upon identification of mosquito genes that condition flavivirus susceptibility and may ultimately provide clues for interrupting transmission. Quantitative trait loci affecting the ability of Ae. aegypti to develop a dengue-2 infection in the midgut have been mapped previously. Herein we report on QTL that determine whether mosquitoes with a dengue-2 infected gut can then disseminate the virus to other tissues. A strain selected for high rates of dengue-2 dissemination was crossed to a strain selected for low dissemination rates. QTL were mapped in the F2, and again in a F5 advanced intercross line. QTL were detected at 31 cM on Chromosome I, at 32 cM on Chromosome II, and between 44-52 cM on Chromosome III. Alleles at these QTL were additive or dominant in determining rates of dengue-2 dissemination and accounted for ~45% of the phenotypic variance. The locations of dengue-2 midgut infection and dissemination QTL correspond to those found in earlier studies.
Key Words: Aedes aegypti, QTL, dissemination, flavivirus, linkage mapping
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