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doi:10.1534/genetics.104.034538
A more recent version of this article appeared on May 1, 2005.
REGULAR RESEARCH PAPERS |
The Ku protein complex is involved in length regulation of Drosophila telomeres
Larisa Melnikova 1, Harald Biessmann 2 and Pavel Georgiev 1*
1 Institute of Gene Biology
2 University of California
* To whom correspondence should be addressed. E-mail: georgiev_p{at}mail.ru.
Submitted on August 8, 2004
Revised on October 16, 2004
Accepted on 31 January 2005
Chromosome ends in Drosophila melanogaster can be elongated either by terminal attachment of telomere-specific retrotransposons, HeT-A and TART, or by terminal gene conversion. Here we show that a decrease in Ku70 or Ku80 gene dosage causes a sharp increase of the frequency of HeT-A and TART attachments to a broken chromosome end and of terminal DNA elongation by gene conversion. Loss of Ku80 has more pronounced effects than loss of Ku70. However, lower Ku70 concentration reduces the stability of terminally deficient chromosomes. Our results suggest a role of the end-binding Ku complex in the accessibility and length regulation of Drosophila telomeres
Key Words: Drosophila, HeT-A, Ku70/80, telomere, terminal chromosome deficiency
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