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doi:10.1534/genetics.104.032631
A more recent version of this article appeared on April 1, 2005.
REGULAR RESEARCH PAPERS |
Flexibility in a Gene Network Affecting a Simple Behavior in Drosophila melanogaster
Bruno van Swinderen 1 and Ralph J. Greenspan 1*
1 The Neurosciences Institute
* To whom correspondence should be addressed. E-mail: greenspan{at}nsi.edu.
Submitted on June 21, 2004
Revised on September 5, 2004
Accepted on 10 January 2005
Gene interactions are emerging as central to understanding the realization of any phenotype. In order to probe the flexibility of interactions in a defined gene network, we isolated a set of 16 interacting genes in Drosophila, based on their alteration of a quantitative behavioral phenotype - the loss of coordination in a temperature-sensitive allele of Syntaxin1A. The interactions inter se of this set of genes were then assayed in the presence and in the absence of the original Syntaxin1A mutation in order to ask whether the relationships among the 16 genes remain stable or differ after a change in genetic context. The pattern of epistatic interactions that occurs within this set of variants is dramatically altered in the two different genetic contexts. The results imply considerable flexibility in the network interactions of genes.
Key Words: Syntaxin1A, behavior, epistasis, gene interactions
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