help button home button Genetics JPET
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Genetics. Published Articles Ahead of Print: September 30, 2004, Copyright © 2004
doi:10.1534/genetics.104.032292

A more recent version of this article appeared on January 1, 2005.
This Article
Right arrow Full Text (Rapid PDF)
Right arrow Supplemental Material
Right arrow All Versions of this Article:
genetics.104.032292v1
genetics.104.032292v2
169/1/265    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Author home page(s):
Jo&atildeo Pedro de Magalh&atildees
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by de Magalh&atildees, J.&a. P.
Right arrow Articles by Magalh&atildees, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Magalh&atildees, J.&a. P.
Right arrow Articles by Magalh&atildees, D.

REGULAR RESEARCH PAPERS

The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging

Jo&atildeo Pedro de Magalh&atildees 1*, Jos&eacute Cabral 2 and Domingos Magalh&atildees 2

1 Harvard Medical School
2 University of Porto

* To whom correspondence should be addressed. E-mail: joao{at}genetics.med.harvard.edu.

Submitted on June 14, 2004
Revised on July 28, 2004
Accepted on 27 September 2004


  Abstract
Genetic interventions that accelerate or retard aging in mice are crucial in advancing our knowledge over mammalian aging. Yet determining if a given intervention affects the aging process is not straightforward since, for instance, many disease-causing mutations may decrease lifespan without affecting aging. In this work, we employed the Gompertz model to determine whether several published interventions previously claimed to affect aging in mice do indeed alter the aging process. Firstly, we constructed age-specific mortality tables for a number of mouse cohorts used in longevity experiments and calculated the rate at which mortality increases with age. Estimates of age-independent mortality were also calculated. We found no statistical evidence that GHRHR, IGF1R, INSR, PROP1, or TRX delay or that ATM + TERC, BubR1, klotho, LMNA, PRDX1, p53, WRN + TERC, or TOP3B accelerated mouse aging. Often, changes in the expression of these genes affected age-independent mortality and so they may prove useful to other aspects of medicine. We found statistical evidence that C/EBP, MSRA, SHC1, growth hormone and GHR, PIT1, and PolgA may influence aging in mice. These results were interpreted together with age-related physiological and pathological changes and provide novel insights regarding the role of several genes in the mammalian aging process.

Key Words: MRDT, lifespan, longevity, rate of aging, statistics




This article has been cited by other articles:


Home page
 Ann. N. Y. Acad. Sci.Home page
I. LENAERTS, S. V. EYGEN, and J. V. FLETEREN
Adult-Limited Dietary Restriction Slows Gompertzian Aging in Caenorhabditis elegans
Ann. N.Y. Acad. Sci., April 1, 2007; 1100(1): 442 - 448.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
J. P. d. Magalhaes, J. Costa, and G. M. Church
An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2007; 62(2): 149 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. S. Bonkowski, J. S. Rocha, M. M. Masternak, K. A. Al Regaiey, and A. Bartke
From the Cover: Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
PNAS, May 16, 2006; 103(20): 7901 - 7905.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Bartke
Minireview: Role of the Growth Hormone/Insulin-Like Growth Factor System in Mammalian Aging
Endocrinology, September 1, 2005; 146(9): 3718 - 3723.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. E. Sonntag, C. S. Carter, Y. Ikeno, K. Ekenstedt, C. S. Carlson, R. F. Loeser, S. Chakrabarty, S. Lee, C. Bennett, R. Ingram, et al.
Adult-Onset Growth Hormone and Insulin-Like Growth Factor I Deficiency Reduces Neoplastic Disease, Modifies Age-Related Pathology, and Increases Life Span
Endocrinology, July 1, 2005; 146(7): 2920 - 2932.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
Papers of Note
Sci. Aging Knowl. Environ., February 2, 2005; 2005(5): nw5 - nw5.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2004 by the Genetics Society of America.