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doi:10.1534/genetics.104.029488
A more recent version of this article appeared on December 1, 2004.
Regular Research Papers |
The Probability and Chromosomal Extent of Trans-Specific Polymorphism
Carsten Wiuf 1, Keyan Zhao 2, Hideki Innan 3 and Magnus Nordborg 2*
1 University of Aarhus
2 USC
3 University of Texas Health Science Center at Houston
* To whom correspondence should be addressed. E-mail: magnus{at}usc.edu.
Submitted on March 30, 2004
Revised on July 26, 2004
Accepted on 7 September 2004
Balancing selection may result in trans-specific polymorphism: the maintenance of allelic classes that transcend species boundaries by virtue of being more ancient than the species themselves. At the selected site, gene genealogies are expected not to reflect the species tree. Because of linkage, the same will be true for part of the surrounding chromosomal region. Here we obtain various approximations for the distribution of the length of this region, and discuss the practical implications of our results. Our main finding is that the trans-specific region surrounding a single-locus balanced polymorphism is expected to be quite short,probably too short to be readily detectable. Thus lack of obvious trans-specific polymorphism should not be taken as evidence against balancing selection. When trans-specific polymorphism is obvious,on the other hand, it may be reasonable to argue that selection must be acting on multiple sites, or that recombination is suppressed in the surrounding region.
Key Words: balancing selection, coalescent theory, molecular evolution, population genetics, speciation
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