help button home button Genetics Journal Watch
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published as Genetics Published Articles Ahead of Print on June 18, 2006.

Genetics, Vol. 173, 2039-2047, August 2006, Copyright © 2006
doi:10.1534/genetics.105.053611

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
genetics.105.053611v1
173/4/2039    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Panhuis, T. M.
Right arrow Articles by Swanson, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Panhuis, T. M.
Right arrow Articles by Swanson, W. J.

Molecular Evolution and Population Genetic Analysis of Candidate Female Reproductive Genes in Drosophila

Tami M. Panhuis1 and Willie J. Swanson

Department of Genome Sciences, University of Washington, Seattle, Washington 98195

1 Corresponding author: Department of Biology, University of California, Riverside, CA 92521.
E-mail: tpanhuis{at}jsd.claremont.edu

Molecular analyses in several taxa have consistently shown that genes involved in reproduction are rapidly evolving and subjected to positive selection. The mechanism behind this evolution is not clear, but several proposed hypotheses involve the coevolution between males and females. In Drosophila, several male reproductive proteins (Acps) involved in male–male and male–female interactions show evidence of rapid adaptive evolution. What has been missing from the Drosophila literature is the identification and analysis of female reproductive genes. Recently, an evolutionary expressed sequence tag analysis of Drosophila female reproductive tract genes identified 169 candidate female reproductive genes. Many of these candidate genes still await further molecular analysis and independent verification of positive selection. Our goal was to expand our understanding of the molecular evolution of Drosophila female reproductive genes with a detailed polymorphism and divergence study on seven additional candidate female reproductive genes and a reanalysis of two genes from the above study. We demonstrate that 6 candidate female genes of the 9 genes surveyed show evidence of positive selection using both polymorphism and divergence data. One of these proteins (CG17012) is modeled to reveal that the sites under selection fall around and within the active site of this protease, suggesting potential differences between species. We discuss our results in light of potential function as well as interaction with male reproductive proteins.




This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
A. Wong, M. C. Turchin, M. F. Wolfner, and C. F. Aquadro
Evidence for Positive Selection on Drosophila melanogaster Seminal Fluid Protease Homologs
Mol. Biol. Evol., March 1, 2008; 25(3): 497 - 506.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
W. Haerty, S. Jagadeeshan, R. J. Kulathinal, A. Wong, K. Ravi Ram, L. K. Sirot, L. Levesque, C. G. Artieri, M. F. Wolfner, A. Civetta, et al.
Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila
Genetics, November 1, 2007; 177(3): 1321 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. K. N. Lawniczak and D. J. Begun
Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster
Mol. Biol. Evol., September 1, 2007; 24(9): 1944 - 1951.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. Jagadeeshan and R. S. Singh
Rapid Evolution of Outer Egg Membrane Proteins in the Drosophila melanogaster Subgroup: A Case of Ecologically Driven Evolution of Female Reproductive Traits
Mol. Biol. Evol., April 1, 2007; 24(4): 929 - 938.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Genetics Society of America.