- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.105.041095v1
170/4/1849 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Garrigan, D.
- Articles by Hammer, M. F.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Garrigan, D.
- Articles by Hammer, M. F.
Originally published as Genetics Published Articles Ahead of Print on June 3, 2005.
Genetics, Vol. 170, 1849-1856, August 2005, Copyright © 2005
doi:10.1534/genetics.105.041095
Deep Haplotype Divergence and Long-Range Linkage Disequilibrium at Xp21.1 Provide Evidence That Humans Descend From a Structured Ancestral Population
Daniel Garrigan*,
,
Zahra Mobasher*,
Sarah B. Kingan*,
Jason A. Wilder*, and
Michael F. Hammer*,,1
* Genomic Analysis and Technology Core, University of Arizona, Tucson, Arizona 85721
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721
1 Corresponding author: Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721.
E-mail: mfh{at}u.arizona.edu
Fossil evidence links human ancestry with populations that evolved from modern gracile morphology in Africa 130,000–160,000 years ago. Yet fossils alone do not provide clear answers to the question of whether the ancestors of all modern Homo sapiens comprised a single African population or an amalgamation of distinct archaic populations. DNA sequence data have consistently supported a single-origin model in which anatomically modern Africans expanded and completely replaced all other archaic hominin populations. Aided by a novel experimental design, we present the first genetic evidence that statistically rejects the null hypothesis that our species descends from a single, historically panmictic population. In a global sample of 42 X chromosomes, two African individuals carry a lineage of noncoding 17.5-kb sequence that has survived for >1 million years without any clear traces of ongoing recombination with other lineages at this locus. These patterns of deep haplotype divergence and long-range linkage disequilibrium are best explained by a prolonged period of ancestral population subdivision followed by relatively recent interbreeding. This inference supports human evolution models that incorporate admixture between divergent African branches of the genus Homo.
This article has been cited by other articles:
 |
|
 |
|
  H. L. Kim and Y. Satta Population Genetic Analysis of the N-Acylsphingosine Amidohydrolase Gene Associated With Mental Activity in Humans Genetics, March 1, 2008; 178(3): 1505 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Garrigan and M. F. Hammer Ancient lineages in the genome: A response to Fagundes et al. PNAS, January 15, 2008; 105(2): E3 - E3. [Full Text] [PDF]
|
|
|
|
|
|
N. J. R. Fagundes, N. Ray, M. Beaumont, S. Neuenschwander, F. M. Salzano, S. L. Bonatto, and L. Excoffier Reply to Garrigan and Hammer: Ancient lineages and assimilation PNAS, January 15, 2008; 105(2): E4 - E4. [Full Text] [PDF]
|
|
|
|
|
|
M. P. Cox, F. L. Mendez, T. M. Karafet, M. M. Pilkington, S. B. Kingan, G. Destro-Bisol, B. I. Strassmann, and M. F. Hammer Testing for Archaic Hominin Admixture on the X Chromosome: Model Likelihoods for the Modern Human RRM2P4 Region From Summaries of Genealogical Topology Under the Structured Coalescent Genetics, January 1, 2008; 178(1): 427 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Shimada, K. Panchapakesan, S. A. Tishkoff, A. Q. Nato Jr, and J. Hey Divergent Haplotypes and Human History as Revealed in a Worldwide Survey of X-Linked DNA Sequence Variation Mol. Biol. Evol., March 1, 2007; 24(3): 687 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Evans, N. Mekel-Bobrov, E. J. Vallender, R. R. Hudson, and B. T. Lahn Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage PNAS, November 28, 2006; 103(48): 18178 - 18183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Geraldes, N. Ferrand, and M. W. Nachman Contrasting Patterns of Introgression at X-Linked Loci Across the Hybrid Zone Between Subspecies of the European Rabbit (Oryctolagus cuniculus) Genetics, June 1, 2006; 173(2): 919 - 933. [Abstract] [Full Text] [PDF]
|
|