- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.104.033704v1
169/1/91 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by van Dyk, D.
- Articles by Bauer, F. F.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by van Dyk, D.
- Articles by Bauer, F. F.
Originally published as Genetics Published Articles Ahead of Print on September 30, 2004.
Genetics, Vol. 169, 91-106, January 2005, Copyright © 2005
doi:10.1534/genetics.104.033704
Mss11p Is a Central Element of the Regulatory Network That Controls FLO11 Expression and Invasive Growth in Saccharomyces cerevisiae
Dewald van Dyk*,
Isak S. Pretorius*,
and
Florian F. Bauer*,1
* Institute for Wine Biotechnology, Department of Viticulture and Oenology, Stellenbosch University, Stellenbosch ZA-7600, South Africa
The Australian Wine Research Institute, Urrbrae, Adelaide SA 5064, South Australia, Australia
1 Corresponding author: Institute for Wine Biotechnology, Department of Viticulture and Oenology, University of Stellenbosch, Matieland 7602, South Africa.
E-mail: fb2{at}sun.ac.za
The invasive and filamentous growth forms of Saccharomyces cerevisiae are adaptations to specific environmental conditions, under particular conditions of limited nutrient availability. Both growth forms are dependent on the expression of the FLO11 gene, which encodes a cell-wall-associated glycoprotein involved in cellular adhesion. A complex regulatory network consisting of signaling pathways and transcription factors has been associated with the regulation of FLO11. Mss11p has been identified as a transcriptional activator of this gene, and here we present an extensive genetic analysis to identify functional relationships between Mss11p and other FLO11 regulators. The data show that Mss11p is absolutely required for the activation of FLO11 by most proteins that have previously been shown to affect FLO11 expression, including the signaling proteins Ras2p, Kss1p, and Tpk2p, the activators Tec1p, Flo8p, and Phd1p, and the repressors Nrg1p, Nrg2p, Sok2p, and Sfl1p. The genetic evidence furthermore suggests that Mss11p activity is not dependent on the presence of any of the above-mentioned factors and that the protein also regulates other genes involved in cellular adhesion phenotypes. Taken together, the data strongly suggest a central role for Mss11p in the regulatory network controlling FLO11 expression, invasive growth, and pseudohyphal differentiation.
This article has been cited by other articles:
 |
|
 |
|
  P. M. R. Guimaraes, J. Francois, J. L. Parrou, J. A. Teixeira, and L. Domingues Adaptive Evolution of a Lactose-Consuming Saccharomyces cerevisiae Recombinant Appl. Envir. Microbiol., March 15, 2008; 74(6): 1748 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Barrales, J. Jimenez, and J. I. Ibeas Identification of Novel Activation Mechanisms for FLO11 Regulation in Saccharomyces cerevisiae Genetics, January 1, 2008; 178(1): 145 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Valerius, M. Kleinschmidt, N. Rachfall, F. Schulze, S. Lopez Marin, M. Hoppert, K. Streckfuss-Bomeke, C. Fischer, and G. H. Braus The Saccharomyces Homolog of Mammalian RACK1, Cpc2/Asc1p, Is Required for FLO11-dependent Adhesive Growth and Dimorphism Mol. Cell. Proteomics, November 1, 2007; 6(11): 1968 - 1979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ma, R. Jin, X. Jia, C. J. Dobry, L. Wang, F. Reggiori, J. Zhu, and A. Kumar An Interrelationship Between Autophagy and Filamentous Growth in Budding Yeast Genetics, September 1, 2007; 177(1): 205 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Dranginis, J. M. Rauceo, J. E. Coronado, and P. N. Lipke A Biochemical Guide to Yeast Adhesins: Glycoproteins for Social and Antisocial Occasions Microbiol. Mol. Biol. Rev., June 1, 2007; 71(2): 282 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Biswas, P. Van Dijck, and A. Datta Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans Microbiol. Mol. Biol. Rev., June 1, 2007; 71(2): 348 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fidalgo, R. R. Barrales, J. I. Ibeas, and J. Jimenez Adaptive evolution by mutations in the FLO11 gene PNAS, July 25, 2006; 103(30): 11228 - 11233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Borneman, J. A. Leigh-Bell, H. Yu, P. Bertone, M. Gerstein, and M. Snyder Target hub proteins serve as master regulators of development in yeast Genes & Dev., February 15, 2006; 20(4): 435 - 448. [Abstract] [Full Text] [PDF]
|
|