THE ACTION OF THE NOTCH LOCUS IN DROSOPHILA MELANOGASTER. II. BIOCHEMICAL EFFECTS OF RECESSIVE LETHALS ON MITOCHONDRIAL ENZYMES

George E. W. Thörig 1, Pieter W. H. Heinstra 1, and Willem Scharloo 1

1 Department of Population and Evolutionary Biology, Rijksuniversiteit Utrecht, The Netherlands

We show that six mapped recessive lethal point mutations of the Notch locus affect mitochondrial enzyme activities: NADH oxidase, NADH dehydrogenase, succinate dehydrogenase and alpha-glycerophosphate dehydrogenase. The mutant N264-40, which has the same morphological and embryological effects as the Notch8 deletion, demonstrates the same biochemical effects and dosage relations as Notch8. The other five mapped recessive lethals also affect four enzymic activities. They show specific patterns of activity that depend in several cases on the wild-type chromosome in the heterozygous females. That effect occurs with mutants located in the extreme right part of the Notch locus where some mutations, according to other authors, show temperature-sensitive expression.

Submitted on April 7, 1981
Revised on July 6, 1981




This article has been cited by other articles:


Home page
 NeurologyHome page
A. Malandrini, F. Albani, S. Palmeri, F. Fattapposta, S. Gambelli, G. Berti, A. Bracco, A. Tammaro, S. Calzavara, M. Villanova, et al.
Asymptomatic cores and paracrystalline mitochondrial inclusions in CADASIL
Neurology, August 27, 2002; 59(4): 617 - 620.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. de la Pena, B. Bornstein, P. del Hoyo, M. A. Fernandez-Moreno, M. A. Martin, Y. Campos, C. Gomez-Escalonilla, J. A. Molina, A. Cabello, J. Arenas, et al.
Mitochondrial dysfunction associated with a mutation in the Notch3 gene in a CADASIL family
Neurology, October 9, 2001; 57(7): 1235 - 1238.
[Abstract] [Full Text] [PDF]