-GLUTAMYL CYCLOTRANSFERASE: A NEW GENETIC POLYMORPHISM IN THE MOUSE (MUS MUSCULUS) LINKED TO LYT–2

Natalie Tulchin ¹ and Benjamin A. Taylor ²

¹ Department of Human Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032
² The Jackson Laboratory, Bar Harbor, Maine 04609

Electrophoretically variant forms of -glutamyl cyclotransferase have been identified in red cells of inbred mouse strains. Each inbred strain exhibited a major band of activity and a minor band that migrated more anodally. The polymorphism affects the migration of both the major and minor bands in a similar way. F₁ hybrids between strains with fast forms (A/J) and strains with the slow forms (C57BL/6J) exhibited a four-banded pattern consistent with co-dominant inheritance. The patterns observed in backcross and F₂ mice were consistent with the segregation of a pair of autosomal co-dominant alleles. Recombinant inbred strains and a congenic strain were used to show that the locus controlling -glutamyl cyclotransferase (Ggc) is linked to Lyt-2, a lymphocyte alloantigen locus on chromosome 6, with an estimated map distance of 5.0 ± 2.5 centimorgans.