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LACK OF GENIC VARIATION IN THE ABUNDANT PROTEINS OF HUMAN KIDNEY
Sandra C. Smith 1, Robert R. Racine 1, and Charles H. Langley 1
1 Laboratory of Animal Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
Abundant proteins of 25 human kidneys were surveyed for genic variation by means of two-dimensional electrophoresis. Eighty-three (83) proteins were scored, and no genic variation was detected. This reduction in genic heterozygosity corroborates results determined with two-dimensional electrophoresis in mice and flies. These results suggest that previous estimates of electrophoretic variation may have been in error because of biased selection of loci.
Submitted on February 14, 1980Revised on October 9, 1980
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